A Case Report of a Primary Small Cell Carcinoma of the Subglottis

  • Hazeem Ahmayuddin School of Medicine, Trinity College, University of Dublin, Ireland
  • Jamsari Khalid Department of Radiation Oncology, The Brunei Cancer Centre, Jerudong, Brunei Darussalam


Small cell carcinoma (SmCC) is a type of cancer affecting the subglottic region of the larynx.Subglottic carcinomas represent only less than 5% of laryngeal cancers, with SmCC accounting for only 0.5%. This case report highlights a patient with a rapidly-progressing laryngeal growth that caused a significant airway obstruction within a period of three weeks. Further investigation revealed that the patient was suffering from a rare form of laryngeal neoplasm, which was consistent with a diagnosis of a limited stage primary SmCC of the subglottis. He was then started on a regimen of radiotherapy with concomitant chemotherapy (cisplatin and etoposide) for a duration of two months. Response to therapy was rapid, with a reduction in tumour size. A combination of radiotherapy and platinum-based chemotherapy is currently the modality of choice for treatment, with recent data showing that surgery has a limited role in laryngeal SmCC.

How to Cite
Ahmayuddin, H., & Khalid, J. (2020). A Case Report of a Primary Small Cell Carcinoma of the Subglottis. Trinity Student Medical Journal , 20(1), Page 3-7. Retrieved from https://www.tsmj.ie/index.php/tsmj/article/view/1543